Stawell police executed the warrant at a London Road property around 7.30am.

A quantity of cash and what is believed to be methylamphetamine and cannabis was seized.

A 31-year-old woman and a 19-year-old man were charged with trafficking ICE and remanded to appear in Horsham Magistrate Court.

A 45-year-old man and an 18-year-old man were charged with drug possession and bailed by police.

They will appear in court at a later date.

Sergeant Matt Cashman said police were keen to speak with anyone who had further information about this type of illegal activity in the area.

"If there are people in the local community who have information then we encourage them to come forward," he said.

"Information can also be provided anonymously via Crime Stoppers and people should be reassured that police will take action.

"Today's arrests should send a clear message to those in the local community that police will not tolerate drug offences and will continue to target those in the Stawell area who engage in this type of criminal behaviour."

Anyone with information is urged to contact Crime Stoppers on 1800 333 000 or make a confidential report at www.crimestoppersvic.com.au