Their goal is to raise at least $4,660 ($10 per kilometre) while walking on the famous St James pilgrimage from Leon to Cape Finisterre in Galicia in north-west Spain.

The trip is estimated to take 19 days.

The ladies are taking the 'trip of a lifetime' on May 17 with a small group of family and friends.

The pilgrimage will take them to the Cathedral of Santiago de Compostela where the remains of St James the Great - one of the 12 apostles - are believed to rest.

Ms Nuske said each year tens of thousands of pilgrims make their way to the cathedral by foot, bicycle, horseback or donkey, where they partake in a pilgrim's mass.

"This journey will be very special to us," Ms Nuske, who is an enrolled nurse and supervisor in Warne House said.

"As long term staff members at Eventide Homes, we couldn't think of a more special way to raise funds for our wonderful facility."

Ms Monaghan, a cook at Eventide, said she was looking forward to interacting with other pilgrims and meeting locals along the way and would mainly stay at pilgrim hostels called albergues.

She said as part of their endurance training, the duo were walking up to 20 kilometres at a time and training at the gym.

Eventide Homes chief executive officer, Sue Blakey encouraged the Stawell community to get behind the fundraiser, which she hopes might raise enough money to purchase iPads for residents' use.

"I think it's going to be really interesting for Eventide residents and the broader community to track what will be an impressive effort by Leeanne and Andrea," Ms Blakey said.

"At Eventide, we'll be exploring famous pilgrimages as a lead up to the trip and have a map so the residents can track their progress."

Donations can be made online (go to Eventide's Facebook page for more information) or at Eventide Homes reception.