TWO people are dead and one was life-threatening injuries after a collision at Black Range, near Stawell, on Wednesday night.
Investigators believe a B-Double truck travelling west on the Western Highway and a semi trailer travelling east collided head-on about 11.30pm.
A third semi-trailer was unable to stop his vehicle in time and collided into the rear of the semi travelling east, leaving the male driver with life-threatening injuries.
All vehicles went up in flames and remained on fire at 5am.
Police have located two bodies at the scene, which are yet to be identified.
The Western Highway will remain closed for most of the day as the investigation continues.
FROM THE SCENE: Twitter user Clinton McNally snapped these pictures just after the crash.
Local detours are in place surrounding the crash site.
Police will prepare a report for the coroner.
Twitter user Clinton McNally was driving along the highway at the time of the crash and took several pictures of the fiery wreckage.
He said the crash happened "just before the railway bridge site" on the Western Highway.
Police, ambulance and CFA rescue were on scene within minutes, but were unable to save the two people.
District 16 Country Fire Authority operations manager Chris Eagle said fire-fighters had been there since about 11.30pm.
He said 20 vehicles attended during the night.
Units from Stawell, Great Western, Ballarat, Wendouree and Ararat were still at the scene, sifting through hot spots in the wreckage.
Mr Eagle said breathing apparatus crews were coming from Willaura, Beaufort and Horsham to help.
"We are hopeful that within the next couple of hours, we can hand over to Victoria Police for their investigations," he said.
It's not known if the deceased were from the local area.